| Year | Tournament | Result | Player | Age | Nation |
|---|---|---|---|---|---|
| 2000 | US Open | R32 | Cédric Pioline | 31 | France |
| 2000 | US Open | R32 | Jérôme Golmard | 26 | France |
| 2000 | US Open | R32 | Jan-Michael Gambill | 23 | United States |
| 2000 | US Open | R32 | Tim Henman | 25 | United Kingdom |
| 2000 | US Open | R32 | Richard Fromberg | 30 | Australia |
| 2000 | US Open | R32 | Agustín Calleri | 23 | Argentina |
| 2000 | US Open | R32 | Amanda Coetzer | 28 | South Africa |
| 2000 | US Open | R32 | Allison Bradshaw | 19 | United States |
| 2000 | US Open | R32 | Elena Likhovtseva | 24 | Russia |
| 2000 | US Open | R32 | Janet Lee | 23 | Taiwan |
| 2000 | US Open | R32 | Shinobu Asagoe | 24 | Japan |
| 2000 | US Open | R32 | Lisa Raymond | 27 | United States |
| 2000 | US Open | R32 | Giulia Casoni | 22 | Italy |
| 2000 | US Open | R32 | Francesca Schiavone | 20 | Italy |
| 2000 | US Open | R32 | Anna Kournikova | 19 | Russia |
| 2000 | US Open | R32 | Tamarine Tanasugarn | 23 | Thailand |
| 2000 | US Open | R32 | Meghann Shaughnessy | 21 | United States |
| 2000 | US Open | R32 | Conchita Martínez | 28 | Spain |
| 2000 | US Open | R32 | Tathiana Garbin | 23 | Italy |
| 2000 | US Open | R32 | Kristie Boogert | 26 | Netherlands |
| 2000 | US Open | R32 | Chanda Rubin | 24 | United States |
| 2000 | US Open | R32 | Adriana Gerši | 24 | Czech Republic |
| 2000 | US Open | R64 | Gianluca Pozzi | 35 | Italy |
| 2000 | US Open | R64 | Stefan Koubek | 23 | Austria |
| 2000 | US Open | R64 | Alexander Popp | 23 | Germany |
| 2000 | US Open | R64 | Karim Alami | 27 | Morocco |
| 2000 | US Open | R64 | Daniel Nestor | 27 | Canada |
| 2000 | US Open | R64 | Cyril Saulnier | 25 | France |
| 2000 | US Open | R64 | Hernán Gumy | 28 | Argentina |
| 2000 | US Open | R64 | Jonas Björkman | 28 | Sweden |
| 2000 | US Open | R64 | Adrian Voinea | 26 | Romania |
| 2000 | US Open | R64 | Albert Costa | 25 | Spain |
| 2000 | US Open | R64 | Marc Rosset | 29 | Switzerland |
| 2000 | US Open | R64 | Ctislav Doseděl | 30 | Czech Republic |
| 2000 | US Open | R64 | Michael Chang | 28 | United States |
| 2000 | US Open | R64 | Greg Rusedski | 26 | United Kingdom |
| 2000 | US Open | R64 | Mark Philippoussis | 23 | Australia |
| 2000 | US Open | R64 | Galo Blanco | 23 | Spain |
| 2000 | US Open | R64 | Xavier Malisse | 20 | Belgium |
| 2000 | US Open | R64 | Jason Stoltenberg | 30 | Australia |
| 2000 | US Open | R64 | André Sá | 23 | Brazil |
| 2000 | US Open | R64 | Andre Agassi | 30 | United States |
| 2000 | US Open | R64 | Jens Knippschild | 25 | Germany |
| 2000 | US Open | R64 | Byron Black | 30 | Zimbabwe |
| 2000 | US Open | R64 | Nicolás Lapentti | 24 | Ecuador |
| 2000 | US Open | R64 | Tommy Haas | 22 | Germany |
| 2000 | US Open | R64 | Justin Gimelstob | 23 | United States |
| 2000 | US Open | R64 | Julien Boutter | 26 | France |
| 2000 | US Open | R64 | Arnaud Di Pasquale | 21 | France |
| 2000 | US Open | R64 | Petr Kralert | 20 | Czech Republic |
Open Era Grand Slam Tennis