| Year | Tournament | Result | Player | Age | Nation |
|---|---|---|---|---|---|
| 2000 | US Open | R64 | Franco Squillari | 25 | Argentina |
| 2000 | US Open | R64 | Wayne Ferreira | 28 | South Africa |
| 2000 | US Open | R64 | Chris Woodruff | 27 | United States |
| 2000 | US Open | R64 | Fernando González | 20 | Chile |
| 2000 | US Open | R64 | Dominique Monami | 27 | Belgium |
| 2000 | US Open | R64 | Dawn Buth | 24 | United States |
| 2000 | US Open | R64 | Jelena Kostanić Tošić | 19 | Croatia |
| 2000 | US Open | R64 | Marissa Irvin | 20 | United States |
| 2000 | US Open | R64 | Anne Kremer | 24 | Luxembourg |
| 2000 | US Open | R64 | Miriam Oremans | 27 | Netherlands |
| 2000 | US Open | R64 | Ruxandra Dragomir | 27 | Romania |
| 2000 | US Open | R64 | Sylvia Plischke | 23 | Austria |
| 2000 | US Open | R64 | Gloria Pizzichini | 25 | Italy |
| 2000 | US Open | R64 | María Vento-Kabchi | 26 | Venezuela |
| 2000 | US Open | R64 | Ai Sugiyama | 25 | Japan |
| 2000 | US Open | R64 | Patty Schnyder | 21 | Switzerland |
| 2000 | US Open | R64 | Lubomira Bacheva | 25 | Bulgaria |
| 2000 | US Open | R64 | María Sánchez Lorenzo | 22 | Spain |
| 2000 | US Open | R64 | Henrieta Nagyová | 21 | Slovakia |
| 2000 | US Open | R64 | Sonya Jeyaseelan | 24 | Canada |
| 2000 | US Open | R64 | Nadia Petrova | 18 | Russia |
| 2000 | US Open | R64 | Nathalie Dechy | 21 | France |
| 2000 | US Open | R64 | Barbara Schett | 24 | Austria |
| 2000 | US Open | R64 | Magdalena Maleeva | 25 | Bulgaria |
| 2000 | US Open | R64 | Jana Kandarr | 23 | Germany |
| 2000 | US Open | R64 | Alicia Molik | 19 | Australia |
| 2000 | US Open | R64 | Tatiana Panova | 24 | Russia |
| 2000 | US Open | R64 | Els Callens | 30 | Belgium |
| 2000 | US Open | R64 | Rita Grande | 25 | Italy |
| 2000 | US Open | R64 | Pavlina Nola | 26 | New Zealand |
| 2000 | US Open | R64 | Sandra Kleinová | 22 | Czech Republic |
| 2000 | US Open | R64 | Virginia Ruano Pascual | 26 | Spain |
| 2000 | US Open | R64 | Iroda Tulyaganova | 18 | Uzbekistan |
| 2000 | US Open | R64 | Kristina Brandi | 23 | Puerto Rico |
| 2000 | US Open | R64 | Květa Peschke | 25 | Czech Republic |
| 2000 | US Open | R64 | Kim Clijsters | 17 | Belgium |
| 2000 | US Open | R128 | Christian Vinck | 24 | Germany |
| 2000 | US Open | R128 | Harel Levy | 22 | Israel |
| 2000 | US Open | R128 | Stéphane Huet | 29 | France |
| 2000 | US Open | R128 | Francisco Clavet | 31 | Spain |
| 2000 | US Open | R128 | Mikael Tillström | 28 | Sweden |
| 2000 | US Open | R128 | Paradorn Srichaphan | 21 | Thailand |
| 2000 | US Open | R128 | Taylor Dent | 19 | United States |
| 2000 | US Open | R128 | Paul Goldstein | 24 | United States |
| 2000 | US Open | R128 | Vince Spadea | 26 | United States |
| 2000 | US Open | R128 | Andreas Vinciguerra | 19 | Sweden |
| 2000 | US Open | R128 | Alberto Martín | 22 | Spain |
| 2000 | US Open | R128 | Cecil Mamiit | 24 | Philippines |
| 2000 | US Open | R128 | Bob Bryan | 22 | United States |
| 2000 | US Open | R128 | Pat Rafter | 27 | Australia |
Open Era Grand Slam Tennis