| Year | Tournament | Result | Player | Age | Nation |
|---|---|---|---|---|---|
| 2025 | US Open | R64 | McCartney Kessler | 26 | United States |
| 2025 | US Open | R64 | Iva Jovic | 17 | United States |
| 2025 | US Open | R64 | Anna Blinkova | 26 | Not representing a country |
| 2025 | US Open | R64 | Anastasia Pavlyuchenkova | 34 | Not representing a country |
| 2025 | US Open | R64 | Liudmila Samsonova | 26 | Not representing a country |
| 2025 | US Open | R64 | Belinda Bencic | 28 | Switzerland |
| 2025 | US Open | R64 | Caty McNally | 23 | United States |
| 2025 | US Open | R64 | Moyuka Uchijima | 24 | Japan |
| 2025 | US Open | R64 | Jeļena Ostapenko | 28 | Latvia |
| 2025 | US Open | R64 | Anastasia Potapova | 24 | Not representing a country |
| 2025 | US Open | R64 | Renata Zarazúa | 27 | Mexico |
| 2025 | US Open | R64 | Zeynep Sönmez | 23 | Turkey |
| 2025 | US Open | R64 | Eva Lys | 23 | Germany |
| 2025 | US Open | R64 | Sorana Cîrstea | 35 | Romania |
| 2025 | US Open | R64 | Kamilla Rakhimova | 23 | Not representing a country |
| 2025 | US Open | R64 | Hailey Baptiste | 23 | United States |
| 2025 | US Open | R64 | Peyton Stearns | 23 | United States |
| 2025 | US Open | R64 | Donna Vekić | 29 | Croatia |
| 2025 | US Open | R64 | Maya Joint | 19 | Australia |
| 2025 | US Open | R64 | Ashlyn Krueger | 21 | United States |
| 2025 | US Open | R64 | Viktorija Golubic | 32 | Switzerland |
| 2025 | US Open | R64 | Anna Bondár | 28 | Hungary |
| 2025 | US Open | R64 | Wang Xinyu | 23 | China |
| 2025 | US Open | R64 | Anastasia Zakharova | 23 | Not representing a country |
| 2025 | US Open | R64 | Yulia Putintseva | 30 | Kazakhstan |
| 2025 | US Open | R64 | Suzan Lamens | 26 | Netherlands |
| 2025 | US Open | R128 | Rebeka Masarova | 26 | Switzerland |
| 2025 | US Open | R128 | Nuria Párrizas Díaz | 34 | Spain |
| 2025 | US Open | R128 | Marie Bouzková | 27 | Czech Republic |
| 2025 | US Open | R128 | Rebecca Marino | 34 | Canada |
| 2025 | US Open | R128 | Alyssa Ahn | 18 | United States |
| 2025 | US Open | R128 | Camila Osorio | 23 | Colombia |
| 2025 | US Open | R128 | Claire Liu | 25 | United States |
| 2025 | US Open | R128 | Clara Tauson | 22 | Denmark |
| 2025 | US Open | R128 | Julieta Pareja | 16 | United States |
| 2025 | US Open | R128 | Lucia Bronzetti | 26 | Italy |
| 2025 | US Open | R128 | Ena Shibahara | 27 | Japan |
| 2025 | US Open | R128 | Veronika Kudermetova | 28 | Not representing a country |
| 2025 | US Open | R128 | Magda Linette | 33 | Poland |
| 2025 | US Open | R128 | Oksana Selekhmeteva | 22 | Not representing a country |
| 2025 | US Open | R128 | Aliaksandra Sasnovich | 31 | Not representing a country |
| 2025 | US Open | R128 | Destanee Aiava | 25 | Australia |
| 2025 | US Open | R128 | Mayar Sherif | 29 | Egypt |
| 2025 | US Open | R128 | Yuliia Starodubtseva | 25 | Ukraine |
| 2025 | US Open | R128 | Hina Inoue | 22 | United States |
| 2025 | US Open | R128 | Dayana Yastremska | 25 | Ukraine |
| 2025 | US Open | R128 | Yuan Yue | 26 | China |
| 2025 | US Open | R128 | Léolia Jeanjean | 30 | France |
| 2025 | US Open | R128 | Rebecca Šramková | 28 | Slovakia |
| 2025 | US Open | R128 | Zhang Shuai | 36 | China |
Open Era Grand Slam Tennis